Shirin Ilkhanizadeh

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This study re-establishes mTOR as a central target in glioma and traces the failure of existing drugs to incomplete/nondurable inhibition of mTORC1 to RapaLink-1, a TORKi linked to rapamycin, with earlier-generation mTOR inhibitors.

TL;DR: It is found that cranial ionizing radiation induced robust and durable PMT in tumors and clinical JAK2 inhibitors should be tested in conjunction with radiation in patients with proneural HGG as a new strategy for blocking the emergence of therapy-resistant mesenchymal tumors at relapse.

TL;DR: This approach provides methodology for detailed studies of human NCC, and clarifies roles for retinoids and BMPs in the differentiation of human PSC to trunk NCC and to sympathoadrenal lineages.

TL;DR: It is demonstrated that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma, and candidate cooperating mutations in Gorlin NES cells are engineered to accelerate tumorigenesis.