Yoon-A Kang

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production, and these results support a dynamic model of blood development in which HSCs convey lineage specification through independent production of distinct lineage-biased MPs that, in turn, support lineage expansion and differentiation.

TL;DR: Fundamental principles underlying GATA factor mechanisms in chromatin are established and a complex network of considerable importance for the control of hematopoiesis is illustrated.

TL;DR: A previously unrecognized dynamic behaviour of GMPs in situ is uncovered, which tunes emergency myelopoiesis and is hijacked in leukaemia.

TL;DR: A novel mechanism by which a master regulator of development establishes a genetic network to instigate cell-type-specific autophagy is illustrated, which is tightly coupled to accumulation of the active form of LC3B and autophagosomes.