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Subramaniam Ganesh

Researcher at Indian Institute of Technology Kanpur

Publications -  108
Citations -  7661

Subramaniam Ganesh is an academic researcher from Indian Institute of Technology Kanpur. The author has contributed to research in topics: Lafora disease & Laforin. The author has an hindex of 31, co-authored 104 publications receiving 6481 citations. Previous affiliations of Subramaniam Ganesh include RIKEN Brain Science Institute & Indian Institutes of Technology.

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mutations in EFHC1 cause juvenile myoclonic epilepsy

Toshimitsu Suzuki, +31 more
- 18 Jul 2004 - 
TL;DR: A new gene is described in this region, EFHC1, which encodes a protein with an EF-hand motif that is associated with juvenile myoclonic epilepsy and which increased R-type Ca2+ currents that were reversed by the mutations associated with JME.
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Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice

Subramaniam Ganesh, +19 more
- 16 May 2002 - 
TL;DR: The results suggest that LD is a primary neurodegenerative disorder that may utilize a non-apoptotic mechanism of cell death and Lafora inclusion bodies predate the onset of impaired behavioral responses, ataxia, spontaneous myoclonic seizures and EEG epileptiform activity.
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Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes

Subramaniam Ganesh, +9 more
- 22 Sep 2000 - 
TL;DR: The results suggest that laforin is involved in translational regulation and that protein misfolding may be one of the molecular bases of the Lafora disease phenotype caused by missense mutations in the EPM2A gene.
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Recent advances in the molecular basis of Lafora’s progressive myoclonus epilepsy

Subramaniam Ganesh, +4 more
- 01 Jan 2006 - 
TL;DR: This review summarises the available information on the genetic basis of LD, and correlates these advances with the rapidly expanding information about the mechanisms of LD gained from studies on both cell biological and animal models.