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Safia Costes

Researcher at University of California, Los Angeles

Publications -  37
Citations -  11394

Safia Costes is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Signal transduction & Autophagy. The author has an hindex of 24, co-authored 36 publications receiving 9883 citations. Previous affiliations of Safia Costes include University of Montpellier & University of Rochester.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

Jacqueline F. Rivera, +4 more
- 01 Aug 2014 - 
TL;DR: It is determined that β cell IAPP content is regulated by autophagy through p62-dependent lysosomal degradation, which indicates thatAutophagy/lysosome degradation defends β cells against proteotoxicity induced by oligomerization-prone human IAPP.
Journal ArticleDOI

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

Julie Quoyer, +11 more
- 15 Jan 2010 - 
TL;DR: This new regulatory mechanism engaged by activated GLP-1R involving a β-arrestin 1-dependent spatiotemporal regulation of the ERK1/2-p90RSK activity is now suspected to participate in the protection of β-cells against apoptosis.
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Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic Β-cells: Protective role of p62-positive cytoplasmic inclusions

Jacqueline F. Rivera, +6 more
- 01 Mar 2011 - 
TL;DR: It is reported that the scaffold protein p62 that delivers polyubiquitinated proteins to autophagy may have a protective role against human-IAPP-induced apoptosis, apparently by sequestrating protein targets for degradation.