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Carmine Settembre

Researcher at Baylor College of Medicine

Publications -  67
Citations -  21444

Carmine Settembre is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Autophagy & TFEB. The author has an hindex of 36, co-authored 56 publications receiving 17851 citations. Previous affiliations of Carmine Settembre include Boston Children's Hospital & Columbia University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

TFEB links autophagy to lysosomal biogenesis.

Carmine Settembre, +17 more
- 17 Jun 2011 - 
TL;DR: A mitogen-activated protein kinase–dependent mechanism regulates autophagy by controlling the biogenesis and partnership of two distinct cellular organelles during starvation.
Journal ArticleDOI

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, +16 more
- 07 Mar 2012 - 
TL;DR: It is shown that the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, colocalizes with master growth regulator mTOR complex 1 (mTORC1) on the lysOSomal membrane and the Rag GTPase complex is both necessary and sufficient to regulate starvation‐ and stress‐induced nuclear translocation of TFEB.
Journal ArticleDOI

Signals from the lysosome: a control centre for cellular clearance and energy metabolism.

Carmine Settembre, +3 more
- 01 May 2013 - 
TL;DR: The identification of a master regulator, transcription factor EB (TFEB), that regulates lysosomal biogenesis and autophagy has revealed how the lyssome adapts to environmental cues, such as starvation, and targeting TFEB may provide a novel therapeutic strategy for modulating lysOSomal function in human disease.