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David C. Chan

Researcher at California Institute of Technology

Publications -  149
Citations -  38683

David C. Chan is an academic researcher from California Institute of Technology. The author has contributed to research in topics: mitochondrial fusion & Mitochondrion. The author has an hindex of 66, co-authored 141 publications receiving 33401 citations. Previous affiliations of David C. Chan include Harvard University & Google.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Hsiuchen Chen, +5 more
- 20 Jan 2003 - 
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
PatentDOI

Core structure of GP41 from the HIV envelope glycoprotein

David C. Chan, +4 more
- 17 Apr 1998 - 
TL;DR: The crystal structure of this complex, composed of the peptides N36 and C34, is a six-helical bundle that shows striking similarity to the low-pH-induced conformation of influenza hemagglutinin and likely represents the core of fusion-active gp41.
Journal ArticleDOI

Mitochondria: Dynamic Organelles in Disease, Aging, and Development

David C. Chan
- 30 Jun 2006 - 
TL;DR: Recent work is discussed that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease.
Journal ArticleDOI

HIV Entry and Its Inhibition

David C. Chan, +1 more
- 29 May 1998 - 
TL;DR: Recent insights in HIV envelope protein structure and function are reviewed and how these findings lead to new approaches for inhibiting HIV entry and may provide insights into the design of better HIV vaccines are reviewed.