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Ju-Hyun Lee

Researcher at New York University

Publications -  49
Citations -  13084

Ju-Hyun Lee is an academic researcher from New York University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 19 publications receiving 11137 citations. Previous affiliations of Ju-Hyun Lee include Nathan Kline Institute for Psychiatric Research.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Ju-Hyun Lee, +19 more
- 25 Jun 2010 - 
TL;DR: It is shown that macroautophagy requires the Alzheimer's disease-related protein presenilin-1 (PS1) for v-ATPase targeting to lysosomes, lysOSome acidification, and proteolysis during autophagy, which represents a basis for pathogenic protein accumulations and neuronal cell death in AD.
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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

W. Haung Yu, +22 more
- 10 Oct 2005 - 
TL;DR: It is shown that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β- amyloidosis.
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Neurodegenerative lysosomal disorders: A continuum from development to late age

Ralph A. Nixon, +2 more
- 02 Jun 2008 - 
TL;DR: A group of neurodegenerative diseases across the lifespan is classed as disorders of lysosomal function, which feature extensive autophagic-endocytic-lysosomal neuropathology and may share mechanisms of Neurodegeneration related to degradative failure and lysOSomal destabilization.