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Michael K. Hancock

Researcher at Invitrogen

Publications -  13
Citations -  4521

Michael K. Hancock is an academic researcher from Invitrogen. The author has contributed to research in topics: Reporter gene & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 13 publications receiving 3605 citations. Previous affiliations of Michael K. Hancock include Life Technologies.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis.

Oksana Sirenko, +7 more
- 01 Sep 2016 - 
TL;DR: The results indicate that a phenotypic assay using 3D model systems formed with human iPSC-derived hepatocytes is suitable for high-throughput screening and can be used for hepatotoxicity assessment in vitro.
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Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.

Jun Wang, +3 more
- 25 Feb 2008 - 
TL;DR: High-throughput cell-based assays for Trk receptor kinases using nuclear factor of activated T-cells (NFAT) beta-lactamase reporter lines stably expressing full length human Trk kinases are developed and demonstrated for their utility in identifying potent and selective modulators of Trk receptors.
Journal ArticleDOI

A quantitative TR-FRET plate reader immunoassay for measuring autophagy

Michael K. Hancock, +2 more
- 24 May 2012 - 
TL;DR: It is demonstrated how this TR-FRET immunoassay for GFP-tagged LC3B-II can be applied to quantitatively detect changes in the autophagy activity of cells, including estimating effects on autophagic flux.
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Phenotypic Assays for Characterizing Compound Effects on Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.

Oksana Sirenko, +6 more
- 01 Aug 2017 - 
TL;DR: This study established high-throughput compatible three-dimensional cardiotoxicity assays using human induced pluripotent stem cell-derived cardiomyocytes to characterize compound effects on the morphology of 3D spheroids.