Zheng-Hong Qin

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Understanding the pathways involved in excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases is of critical importance for the future clinical treatment of many neurodegening diseases.

TL;DR: A highly efficient molecular delivery technique, named nanotube spearing, based on the penetration of nickel-embedded nanotubes into cell membranes by magnetic field driving is reported, achieving an unprecedented high transduction efficiency in Bal17 B-lymphoma, ex vivo B cells and primary neurons with high viability after transduction.

TL;DR: These conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process, including the Lurcher mouse and a range of chronic neurodegenerative conditions.

TL;DR: The current understanding of the molecular and cellular mechanisms of excitotoxicity and their roles in the pathogenesis of diseases of the central nervous system are discussed.