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Jian Lin

Researcher at Peking University

Publications -  57
Citations -  6488

Jian Lin is an academic researcher from Peking University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 20, co-authored 46 publications receiving 5112 citations.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Biosensor Based on Ultrasmall MoS2 Nanoparticles for Electrochemical Detection of H2O2 Released by Cells at the Nanomolar Level

TL;DR: An extremely sensitive H2O2 biosensor based on MoS2 nanoparticles with a real determination limit as low as 2.5 nM and wide linear range of 5 orders of magnitude was constructed, and an efficient glucose biosensor was also fabricated.
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Multifunctional Fe5 C2 nanoparticles: a targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy.

TL;DR: Fe5 C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell.
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Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells.

TL;DR: An mTagRFP-mWasabi-LC3 reporter is reported, in which mWasabi is more acid sensitive than EGFP and has no fluorescence in acidic lysosomes, and the results suggest that the dosage of chemical autophagy inducers would obviously influence autophagic flux in cells.
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Monodisperse Au–Fe2C Janus Nanoparticles: An Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy

TL;DR: Monodisperse Au-Fe2C Janus nanoparticles of 12 nm, used as a multifunctional nanoplatform, allow the combination of multiple-model imaging techniques and high therapeutic efficacy and have great potential for precision theranostic nanomedicines.