scispace - formally typeset
K

Keisuke Obara

Researcher at Hokkaido University

Publications -  31
Citations -  5829

Keisuke Obara is an academic researcher from Hokkaido University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 16, co-authored 26 publications receiving 4781 citations. Previous affiliations of Keisuke Obara include Nagoya University & National Institute for Basic Biology, Japan.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

Keisuke Obara, +3 more
- 29 Aug 2008 - 
TL;DR: Taken together, Atg18 forms a complex with Atg2 irrespective of PtdIns(3)P binding, associates tightly to autophagic membranes by interacting with Ptdins 3,5-bisphosphate, and plays an essential role.
Journal ArticleDOI

Assortment of Phosphatidylinositol 3-Kinase Complexes—Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure in Saccharomyces cerevisiae

Keisuke Obara, +2 more
- 01 Apr 2006 - 
TL;DR: Results indicate that complexes I and II function in distinct biological processes by localizing to specific compartments in a manner mediated by specific components of each complex, Atg14p and Vps38p, respectively.
Journal ArticleDOI

Structure of Atg5·Atg16, a Complex Essential for Autophagy

Minako Matsushita, +5 more
- 02 Mar 2007 - 
TL;DR: The results taken together suggest that the direct interaction between Atg5 and Atg16 is crucial to the performance of their roles in autophagy.
Journal ArticleDOI

Transport of phosphatidylinositol 3‐phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

Keisuke Obara, +3 more
- 01 Jun 2008 - 
TL;DR: It is shown that the lipid‐kinase activity of Vps34 is required for autophagy, implying an essential role of its product PtdIns(3)P, which was highly enriched and delivered into the vacuole as a component of autophagosome membranes but not as a cargo enclosed within them, implying direct involvement of this phosphoinositide in autophagic formation.