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Simone Engelender

Researcher at Technion – Israel Institute of Technology

Publications -  72
Citations -  15173

Simone Engelender is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Parkin & Parkinson's disease. The author has an hindex of 36, co-authored 69 publications receiving 13370 citations. Previous affiliations of Simone Engelender include Johns Hopkins University School of Medicine & Johns Hopkins University.

Papers
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1 : implications for Lewy body formation

Kah-Leong Lim, +12 more
- 23 Feb 2005 - 
TL;DR: The results suggest that parkin is a dual-function ubiquitin ligase and that K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with PD.
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Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

Yuji Tanaka, +9 more
- 15 Apr 2001 - 
TL;DR: In this article, the authors showed that expression of mutant alpha-synuclein results in sensitivity to impairment of proteasome activity, leading to mitochondrial abnormalities and neuronal cell death in Parkinson's disease.
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Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

Simone Engelender, +13 more
- 01 May 1999 - 
TL;DR: It is found that α-synuclein interacts in vivo with synphilin-1 in neurons, and co-transfection of both proteins (but not control proteins) in HEK 293 cells yields cytoplasmic eosinophilic inclusions.