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Toshiyuki Nakagawa

Researcher at Gifu University

Publications -  38
Citations -  10053

Toshiyuki Nakagawa is an academic researcher from Gifu University. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 17, co-authored 34 publications receiving 8880 citations. Previous affiliations of Toshiyuki Nakagawa include Japanese Foundation for Cancer Research & National Agriculture and Food Research Organization.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.

Toshiyuki Nakagawa, +6 more
- 06 Jan 2000 - 
TL;DR: It is shown that caspase-12 is localized to the ER and activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals, which may contribute to amyloid-β neurotoxicity.
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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis.

Toshiyuki Nakagawa, +1 more
- 21 Aug 2000 - 
TL;DR: It is proposed that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid β peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation, suggesting a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspases families.
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Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor

Mutsuo Matsumoto, +20 more
- 11 Jan 1996 - 
TL;DR: It is reported that most IP3R1-deficient mice generated by gene targeting die in utero, and born animals have severe ataxia and tonic or tonic-clonic seizures and die by the weaning period and an electroencephalogram showed that they suffer from epilepsy.
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The Xenopus IP3 receptor: Structure, function, and localization in oocytes and eggs

Shoen Kume, +11 more
- 07 May 1993 - 
TL;DR: Immunocytochemical studies and cDNA clones encoding IP3R expressed in the Xenopus oocytes revealed polarized distribution of XIP3R in the cytoplasm of the animal hemisphere in a well-organized endoplasmic reticulum-like structure and intensive localization in the perinuclear region of stage VI immature oocytes.