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Irena Manov

Researcher at University of Haifa

Publications -  34
Citations -  5268

Irena Manov is an academic researcher from University of Haifa. The author has contributed to research in topics: Spalax & DNA damage. The author has an hindex of 16, co-authored 32 publications receiving 4277 citations. Previous affiliations of Irena Manov include Technion – Israel Institute of Technology & Rappaport Faculty of Medicine.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Monoubiquitylation of α-Synuclein by Seven in Absentia Homolog (SIAH) Promotes Its Aggregation in Dopaminergic Cells

Ruth Rott, +8 more
- 08 Feb 2008 - 
TL;DR: It is reported that the ubiquitin-protein isopeptide ligase seven in absentia homolog (SIAH) directly interacts with and monoubiquitylates α-synuclein and promotes its aggregation in vitro and in vivo, which is toxic to cells.
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Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence.

Irena Manov, +7 more
- 09 Aug 2013 - 
TL;DR: This report provides pioneering evidence that Spalax is not only resistant to spontaneous cancer but also to experimentally induced cancer, and shows the unique ability ofSpalax normal fibroblasts to inhibit growth and kill cancer cells, but not normal cells, either through direct fibroblast-cancer cell interaction or via soluble factors.
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Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.

Irena Manov, +2 more
- 01 Jan 2002 - 
TL;DR: The role of apoptosis and oxidative damage as putative mechanisms of AAP-associated cytotoxicity are studied and it is found that in Hep3B cells, AAP causes a time- and concentration-dependent cytotoxic effect, leading to oxidative stress, mitochondrial dysfunction, alterations of membrane permeability and apoptosis.
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The hepatic mitochondrial DNA depletion syndrome: ultrastructural changes in liver biopsies.

Hanna Mandel, +5 more
- 01 Oct 2001 - 
TL;DR: Although individual ultrastructural findings are not specific, when taken together, they show a diagnostic pattern highly suggestive of a respiratory chain disorder in liver tissue, and can direct the clinician towards the diagnosis of hepatic MDS.