Antonio Piras

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The AMD retina can represent a valuable model to study neuroinflammation, its mechanisms and therapy in a restricted and controllable environment and could represent a new way to treat and prevent both exudative and dry forms of AMD.

TL;DR: Targeting autophagy with 3-methyladenine partially prevented death of neurons and reduces apoptotic markers, 24 h post-lesion, and could represent a novel and promising treatment for glaucoma and retinal ischemia.

TL;DR: HMSC transplantation prevented the downregulation of the anti-inflammatory interleukin-10, as well as that of vascular endothelial growth factor observed in saline-treated transgenic mice compared with wild type, and resulted in a dramatic increase in the expression of theAnti-inflammatoryinterleukIn-13.

TL;DR: Data presented in this work show a link for autophagy and apoptosis with monomers and oligomers, respectively, which are likely to help the design of novel disease modifying therapies.