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Shoba Amarnath

Researcher at Newcastle University

Publications -  38
Citations -  6179

Shoba Amarnath is an academic researcher from Newcastle University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 17, co-authored 38 publications receiving 4956 citations. Previous affiliations of Shoba Amarnath include National Institutes of Health & University of Pennsylvania.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.

Shoba Amarnath, +14 more
- 30 Nov 2011 - 
TL;DR: It is shown that an inhibitory protein called programmed death ligand 1 (PDL1) can regulate renegade immune cells by converting immune response–promoting T helper type 1 (TH1) cells to regulatory T (Treg) cells—agents that selectively suppress activation of the immune system.
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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Benjamin J. Fowler, +21 more
- 21 Nov 2014 - 
TL;DR: NRTIs improved outcomes in several NLRP3 inflammasome-dependent mouse models of inflammation, including age-related macular degeneration and graft-versus-host disease, and suggest that NRTIs are ripe for drug repurposing in P2X7-driven diseases.
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STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells During Acute Murine Graft Versus Host Disease

Arian Laurence, +7 more
- 24 Aug 2012 - 
TL;DR: It is found STAT3 limited FoxP3(+) Treg cell numbers following allogeneic BMT by two pathways: instability of natural Treg cells and inhibition of induced Treg (iTreg) cell polarization from naive CD4(+) T cells.
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PD-1 regulates KLRG1+ group 2 innate lymphoid cells.

Samuel Taylor, +15 more
- 05 Jun 2017 - 
TL;DR: It is demonstrated here that PD-1 is an important negative regulator of KLRG1+ ILC-2 function in both mice and humans and is required for maintaining the number, and hence function, of K LRG1-2s.