Wei Lien Yen

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Evidence is provided for the involvement of exocytic Q/t-SNAREs in autophagosome formation, acting in the recruitment of key autophagy components to the site of autophagic formation, and in regulating the organization of Atg9 into tubulovesicular clusters.

TL;DR: The role of autophagy is reviewed, with an emphasis on the signaling pathways that are involved in regulation, and the consequences ofautophagy induction with regard to aging.

TL;DR: A genome-wide yeast mutant screen forMitophagy-defective strains identified 32 mutants with a block in mitophagy, in addition to the known autophagic-related (ATG) gene mutants, and characterized one of these mutants, ylr356wDelta that corresponds to a gene whose function has not been identified.

TL;DR: It is proposed that a pool of Atg11 mediates the anterograde transport of AtG9 to the PAS that is dependent on the actin cytoskeleton during yeast vegetative growth.