Diane C. Fingar

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Evidence indicates that the mTORC1-S6K1 axis controls, at least in part, glucose homoeostasis, insulin sensitivity, adipocyte metabolism, body mass and energy balance, tissue and organ size, learning, memory and aging.

TL;DR: Recent progress in the understanding of the regulation and function of mTOR signaling networks in cellular physiology is reviewed.

TL;DR: This work reviews the growing knowledge of cellular mTOR regulation by diverse upstream signals and how mTORC1 integrates these signals to effect appropriate downstream signaling, with a greater emphasis on m TORC1 over mTOC2.

TL;DR: The data provide a novel regulatory mechanism by which mitogenic and oncogenic activation of the Ras/MAPK pathway promotes mTOR signaling, and three proline-directed residues within Raptor, Ser8, Ser696, and Ser863, which are directly phosphorylated by ERK1/2 are found.