Xiangmei Chen

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Infusion of Ang II, AT1 blockers, or an AT2 blocker was without effect on blood pressure in Agtr1a-/-; Agtr 1b-/- mice, indicating that AT2 receptor does not exert acute depressor effects in these mice lacking AT1 receptors.

TL;DR: The data demonstrate that necroptosis is a major mechanism of proximal tubular cell death in cisplatin-induced nephrotoxic AKI, and a positive feedback loop involving these genes and inflammatory cytokines that promotes ne croptosis progression.

TL;DR: The observed absence of the abnormal phenotypes in Agtr1b -/- mice indicates that 1) AT1A receptors can take over the role of AT1B receptors in AgTr1b-/- mice or 2) functionally significant non- AT1, non-AT2 receptor(s) may exist for the action of angiotensin.