Patricia V. Schoenlein

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These studies provide the first evidence that macroautophagy plays a critical role in the development of antiestrogen resistance, and propose that targeting autophagosome function will improve the efficacy of hormonal treatment of ER+ breast cancer.

TL;DR: It is shown that the transporter is up-regulated specifically in estrogen receptor (ER)-positive breast cancer, demonstrable with primary human breast cancer tissues andhuman breast cancer cell lines, and an effective drug target for the treatment of ER- positive breast cancer.

TL;DR: Evidence is provided that homocysteine is toxic to neurons of the ganglion cell layer and evidence that these retinal neurons are dying by apoptosis is provided, and it is demonstrated for the first time that excitotoxic damage to neuron of the Ganglion Cell layer is potentiated by simultaneous elevation of homocy steine and glutamate.

TL;DR: Analysis of a representative resistant cell line showed an increased ability of the cells to sustain high levels of antiestrogen-induced autophagy without progression to death, and blockade of autophagosome function in the 4-OHT-treated, antiestrogens-resistant cells induced a robust death response.