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Alison Simmons

Researcher at Medical Research Council

Publications -  101
Citations -  10816

Alison Simmons is an academic researcher from Medical Research Council. The author has contributed to research in topics: Innate immune system & Gene. The author has an hindex of 27, co-authored 89 publications receiving 7833 citations. Previous affiliations of Alison Simmons include University of Oxford & National Institute for Health Research.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Rachel Cooney, +13 more
- 01 Jan 2010 - 
TL;DR: It is shown that NOD2-mediated autophagy is required for both bacterial handling and generation of major histocompatibility complex (MHC) class II antigen-specific CD4+ T cell responses in DCs, and defects in this pathway in Crohn's disease DCs are revealed.
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Katrina M. de Lange, +39 more
- 01 Feb 2017 - 
TL;DR: This work identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that have been identified as important therapeutic targets in inflammatory bowel disease and identified 3 associated variants that are correlated with expression changes in response to immune stimulus at two of these genes.
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Colonic epithelial cell diversity in health and inflammatory bowel disease

Kaushal Parikh, +34 more
- 27 Feb 2019 - 
TL;DR: Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.
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Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

James Kinchen, +19 more
- 04 Oct 2018 - 
TL;DR: This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.