Katarina Kågedal

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death.

TL;DR: A growing body of evidence suggests that LMP may be governed by several distinct mechanisms that are likely engaged in a death stimulus- and cell-type-dependent fashion, and factors contributing to permeabilization of the lysosomal membrane including reactive oxygen species, lysOSomal membrane lipid composition, proteases, p53, and Bcl-2 family proteins are described.

TL;DR: An improved in vitro model, generating sustainable cells with morphology and biochemistry of human, mature neurons, useful in many areas of neuroscience research, particularly the Alzheimer's disease field is developed.