John P. Aris

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Recent studies that have converged at a consensus regarding the involvement of mitochondrial dynamics in key cellular processes are discussed, and a possible link between abnormal mitochondrial dynamics and aging is introduced.

TL;DR: The resurrection of the last common ancestor of Adh1 and Adh2, called AdhA is reported, which suggests that the ancestor was optimized to make (not consume) ethanol, consistent with the hypothesis that before the Adh 1-Adh2 duplication, yeast did not accumulate ethanol for later consumption but rather used AdHA to recycle NADH generated in the glycolytic pathway.

TL;DR: Findings demonstrate important roles for autophagy and amino acid homeostasis in determining CLS in yeast and indicate that activation of GAAC reduces CLS whereas suppression ofGAAC extends CLS in minimal medium.

TL;DR: It is reported that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.