Chi Hin Cho

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Elucidating the biological aspects of miRNA dysregulation may help to better understand the pathogenesis of gastric cancer and promote the development of mi RNA-directed therapeutics against this deadly disease.

TL;DR: Given that the drug resistance mechanisms are different among colon cancer patients and may change even in a single patient at different stages, personalized and specific combination therapy is proposed to be more effective and safer for the reversal of drug resistance in clinics.

TL;DR: Modulation of autophagy is a novel approach for enhancing the efficacy of existing cancer therapy, but its Janus-faced nature may complicate the clinical development of Autophagy modulators as anticancer therapeutics.

TL;DR: It is demonstrated that oral nicotine administration for 25 days stimulated growth of human colon cancer xenograft in nude mice and increased vascularization in the tumors and elevated cotinine and adrenaline plasma levels, providing direct evidence that nicotine can enhance colon tumor growth mediated partly by stimulation of beta-adrenoceptors, preferentially the beta(2)-adrenOceptors.