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David J. McConkey

Researcher at University of Texas MD Anderson Cancer Center

Publications -  327
Citations -  37822

David J. McConkey is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Apoptosis & Bladder cancer. The author has an hindex of 97, co-authored 301 publications receiving 34917 citations. Previous affiliations of David J. McConkey include University of Texas Health Science Center at Houston & Harvard University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Comprehensive molecular characterization of urothelial bladder carcinoma

John N. Weinstein, +296 more
- 01 Jan 2014 - 
TL;DR: Ch Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities.
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Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

Woonyoung Choi, +21 more
- 10 Feb 2014 - 
TL;DR: P53-like MIBCs were consistently resistant to neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy, and all chemoresistant tumors adopted a p53- like phenotype after therapy.
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Role of Ca2+ in toxic cell killing

Sten Orrenius, +3 more
- 01 Jul 1989 - 
TL;DR: Several biochemical mechanisms that are stimulated by a sustained increase in cytosolic Ca2+ concentration and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components are described.
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Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

Thiruvengadam Arumugam, +9 more
- 15 Jul 2009 - 
TL;DR: In this article, the authors characterized patterns of sensitivity and resistance to three conventional chemotherapeutic agents with divergent mechanisms of action [gemcitabine, 5-fluorouracil (5-FU), and cisplatin] in pancreatic cancer cells.