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Richard C. Wang

Researcher at University of Texas Southwestern Medical Center

Publications -  61
Citations -  7944

Richard C. Wang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Merkel cell polyomavirus & Internal medicine. The author has an hindex of 26, co-authored 54 publications receiving 6477 citations. Previous affiliations of Richard C. Wang include University of Texas at Austin & University of Texas System.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

Richard C. Wang, +8 more
- 16 Nov 2012 - 
TL;DR: It is shown that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kinase Akt, and Akt-mediated phosphorylation of BeClin 1 functions in Autophagy inhibition, oncogenesis, and the formation of an autophile-inhibitory BeclIn 1/14-3-3/vimentin intermediate filament complex.
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Homologous recombination generates T-loop-sized deletions at human telomeres.

Richard C. Wang, +2 more
- 29 Oct 2004 - 
TL;DR: Findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres.
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Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

Peter J. Siska, +24 more
- 15 Jun 2017 - 
TL;DR: Strategies to improve metabolic function of ccRCC CD8 TIL may promote the immune response toccRCC, and provision of pyruvate to bypass glycolytic defects or scavengers to neutralize mitochondrial ROS could partially restore TIL activation.
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Tel2 Regulates the Stability of PI3K-Related Protein Kinases

Hiroyuki Takai, +4 more
- 28 Dec 2007 - 
TL;DR: While Tel2 deletion did not alter PIKK mRNA levels, in vivo pulse labeling experiments showed that Tel2 controls the stability of ATM and mTOR, identifying Tel2 as a highly conserved regulator of PIKK stability.