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Yan Cheng

Researcher at Pennsylvania State University

Publications -  24
Citations -  5991

Yan Cheng is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Autophagy & Protein kinase B. The author has an hindex of 19, co-authored 24 publications receiving 4903 citations. Previous affiliations of Yan Cheng include Penn State Cancer Institute & Penn State Milton S. Hershey Medical Center.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology

Yan Cheng, +3 more
- 01 Oct 2013 - 
TL;DR: A better understanding of the biology of Autophagy and the pharmacology of autophagy modulators has the potential for facilitating the development ofAutophagy-based therapeutic interventions for several human diseases.
Journal ArticleDOI

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

Yan Cheng, +12 more
- 18 Jul 2013 - 
TL;DR: A new function and mechanism is revealed for Sirt3 in defending the mitochondrial genome against oxidative damage and protecting from the genotoxic stress-induced apoptotic cell death but also provides evidence supporting a new mtDNA repair pathway.
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Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

Yujuan Chen, +6 more
- 06 Feb 2014 - 
TL;DR: This review focuses on highlighting the Janus role of SIRT3 with oncogenic or tumor-suppressive function in cancer, which may provide more new clues for exploring Sirt3 as a therapeutic target for drug discovery.
Journal ArticleDOI

eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206

Yan Cheng, +10 more
- 01 Apr 2011 - 
TL;DR: Regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206 are investigated, suggesting that targeting eEF-2 kinase may reinforce the antitumor efficacy of Akt inhibitors such as MK- 2206.