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Lotta Agholme

Researcher at University of Gothenburg

Publications -  27
Citations -  5644

Lotta Agholme is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Cellular differentiation & Neurodegeneration. The author has an hindex of 14, co-authored 26 publications receiving 4490 citations. Previous affiliations of Lotta Agholme include Prince of Wales Medical Research Institute & Linköping University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

Lotta Agholme, +4 more
- 01 Jan 2010 - 
TL;DR: An improved in vitro model, generating sustainable cells with morphology and biochemistry of human, mature neurons, useful in many areas of neuroscience research, particularly the Alzheimer's disease field is developed.
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Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of β-Amyloid

Sangeeta Nath, +5 more
- 27 Jun 2012 - 
TL;DR: Observations support that intracellular Aβ oligomers play a role in neurodegeneration, and they explain the manner in which Aβ can drive disease progression, even if the extracellular plaque load is poorly correlated with the degree of cognitive decline.
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Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

Jakob Domert, +6 more
- 01 May 2014 - 
TL;DR: It is shown that different Aβ-isoforms (fluorescently labeled 1-42, 3(pE)-40, 1-40 and 11-42 oligomers) can transfer from one cell to another, and oAβ1-42 is a potentially toxic isoform.
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Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease.

Andrea Armstrong, +12 more
- 01 Mar 2014 - 
TL;DR: Findings indicate that increased levels of LAMP-1, Lamp-2, LC3, Rab3 and Rab7 in the CSF might be specific for AD, and increased EEA1 levels may be a sign of general neurodegeneration.