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Javier Alegre-Abarrategui

Researcher at University of Oxford

Publications -  25
Citations -  6118

Javier Alegre-Abarrategui is an academic researcher from University of Oxford. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 17, co-authored 23 publications receiving 4823 citations. Previous affiliations of Javier Alegre-Abarrategui include Imperial College London & Wellcome Trust Centre for Human Genetics.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

Javier Alegre-Abarrategui, +6 more
- 01 Nov 2009 - 
TL;DR: The functional involvement of LRRK2 in the endosomal-autophagic pathway and the recruitment to specific membrane microdomains in a physiological human gene expression model is demonstrated suggesting a novel function for this important PD-related protein.
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Alpha-synuclein oligomers: a new hope

Nora Bengoa-Vergniory, +3 more
- 01 Dec 2017 - 
TL;DR: The advances in understanding of the role of alpha-synuclein in Parkinson’s disease that may be brought about by the specific and sensitive detection of distinct oligomeric species in post-mortem patient brain are discussed.
Journal ArticleDOI

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

Rosalind F. Roberts, +2 more
- 01 Jun 2015 - 
TL;DR: A new method for the direct detection of alpha-synuclein oligomers – the alpha- synuclein proximity ligation assay – is presented and previously unrecognised early-stage pathology in Parkinson’s disease post-mortem tissue is revealed.
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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Devika Agarwal, +12 more
- 21 Aug 2020 - 
TL;DR: It is shown that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways.