Andreas Wyttenbach

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is proposed that a poly(Q) mutation can induce ROS that directly contribute to cell death and that HSP27 is an antagonist of this process, and this chaperone protects cells against oxidative stress.

TL;DR: To the knowledge, this is the first report of an HSP increasing aggregation of an abnormally folded protein in mammalian cells and expands the current understanding of the roles of HDJ-2/HSDJ in protein folding.

TL;DR: Stable inducible neuronal (PC12) cell lines that express huntingtin exon 1 with varying CAG repeat lengths under doxycycline (dox) control suggest novel targets for the HD mutation and were compatible with impaired cAMP response element (CRE)-mediated transcription, which was confirmed using CRE-luciferase reporter assays.

TL;DR: The relative importance of protein synthesis and autophagy in ageing is discussed, how TOR regulates translation and autophile regulation is identified and links between the TOR signaling network and ageing pathways are speculated on.