Qiuhong Duan

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this paper , a review of the role of BCAAs metabolic disorders in different tumor types by focusing on the impacts of metabolic disorders of BAAs and discussing the notable proteins involved in cancer metabolic reprogramming of BAUs, such as BCAT1/2, BCKDH-BCKDK-PPM1K complex, transporters of BAIs and its metabolites, transcription factors and so on, and present several possible diagnose approaches and therapies to BAAs-related cancers.

TL;DR: It is demonstrated that BCKDK promotes OC proliferation and migration by activating the MEK/ERK signaling pathway and targeting the BCK DK-MEK axis may provide a new therapeutic strategy for treating patients with OC.

TL;DR: The role of TOPK in targeted cancer therapy was concluded, its tumor-related signaling network and known TOPK inhibitors were summarized, and future research directions for TOPK were assessed.

TL;DR: In this paper , the combination of alectinib and HI-032 (a TOPK inhibitor) suppressed the growth and promoted the apoptosis of ALK-positive NSCLC cells ex vivo and in vivo.