Ana Milojkovic

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Although drug-mediated oncogene inactivation selectively killed the cancer cells and left the tumor vasculature intact, which likely facilitated survival and growth of resistant clones, T(E) cell treatment led to blood vessel destruction and probably "bystander" elimination of escape variants, which did not require antigen cross-presentation by stromal cells.

TL;DR: The data indicate that in the absence of functional p53 and Bax, p14ARF triggers mitochondrial apoptosis signaling by activating Bak, which is facilitated by down-regulating anti-apoptotic Mcl-1 and Bcl-xL.

TL;DR: The inverse relation of apoptosis and polyploidy induction by paclitaxel or nocodazole in BL is found and it should be of great importance to overcome therapy resistance and therapy-related events that result in ploidy changes and tumor progression.

TL;DR: It is shown that p14ARF-induced mitochondrial apoptosis critically depends on the BH3-only protein Puma, and that the sensitivity of Puma-deficient cells to p14 ARF- induced apoptosis is fully restored by functional reconstitution ofPuma using a conditional adenoviral expression vector.