Takao Setoguchi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that in the absence of serum the combination of basic fibroblast growth factor and platelet-derived growth factor maintains SP cells in the C6 glioma cell line, and proposed that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy.

TL;DR: It is suggested that inhibition of Notch pathway suppresses osteosarcoma growth by regulation of cell cycle regulator expression and that the inactivation of the notch pathway may be a useful approach to the treatment of patients with osteosARcoma.

TL;DR: The results suggest that increase in the expression of BMP7 promotes survival of neurons and glial cells after acute traumatic injury, suggesting that injury-upregulated B MP7 may regulate differentiation ofglial cells from neural progenitors and may induce gliosis after central nervous system injury.