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Scott M. Welford

Researcher at Case Western Reserve University

Publications -  44
Citations -  6730

Scott M. Welford is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 20, co-authored 35 publications receiving 5553 citations. Previous affiliations of Scott M. Welford include University of California, Los Angeles & Stanford University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

TL;DR: It is shown that HIF1 regulates the expression of mir-210 in a variety of tumor types through a hypoxia-responsive element, suggesting an important role for mir- 210 in regulating the hypoxic response of tumor cells and tumor growth.
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HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

TL;DR: The studies identify HIF control of fatty acid metabolism as essential for ccRCC tumorigenesis by identifying the rate-limiting component of mitochondrial fatty acid transport, carnitine palmitoyltransferase 1A (CPT1A), as a direct HIF target gene.
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Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization.

TL;DR: The use of RDA essentially provides an enriched library of differentially expressed genes, while analysis of this library with microarrays allows rapid and reproducible screening of thousands of DNA molecules simultaneously.
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The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.

TL;DR: It is demonstrated that Akt hyperactivation and HIF1alpha induction by normally occurring hypoxia in the skin significantly contribute to melanoma development.