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Michel Roberge

Researcher at University of British Columbia

Publications -  142
Citations -  15084

Michel Roberge is an academic researcher from University of British Columbia. The author has contributed to research in topics: Autophagy & G2-M DNA damage checkpoint. The author has an hindex of 39, co-authored 140 publications receiving 13387 citations. Previous affiliations of Michel Roberge include University of California, Davis & Dalhousie University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Aruna D. Balgi, +7 more
- 22 Sep 2009 - 
TL;DR: The observation that drugs already approved for human use can reversibly inhibit m TORC1 and stimulate autophagy should greatly facilitate the preclinical and clinical testing of mTORC1 inhibition for indications such as tuberous sclerosis, diabetes, cardiovascular disease and cancer.
Journal ArticleDOI

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

Edward A. Sausville, +14 more
- 15 Apr 2001 - 
TL;DR: Preliminary evidence suggests UCN-01 modulation of both PKC substrate phosphorylation and the DNA damage-related G(2) checkpoint may be responsible for disease stability in refractory neoplasms.
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Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.

Gloria Juan, +8 more
- 01 Jun 1998 - 
TL;DR: Analysis of phosphorylation of H3 in individual cells when combined with multiparameter analysis of their cycle position and expression of other proteins offers new possibilities to study molecular mechanisms associated with the G2 to M transition and chromatin condensation.