Zelda H. Cheung

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Immunohistochemical analysis revealed that caspases-3 and -9 activation in the RGCs were not detected until day 3 post-axotomy, coinciding with the onset of axotomy-induced RGC loss, indicating that the PI3K/Akt pathway may serve as an endogenous regulator of caspase activation in axotomized R GCs, contributing to the late onset of RGC death following axotomy.

TL;DR: This study demonstrates that herbs can act as a potential neuroprotective agent for damaged RGCs and suggests that the therapeutic value of herbal remedies can be maximized by the use of mixtures of appropriate herbs.

TL;DR: Data here suggest that Menta-FX displayed a PI3K-dependent, selective inhibition on a caspase-3-independent apoptotic pathway in axotomized RGCs, thus, highlighting the potential use of herbal remedies as neuroprotective agents for other neurodegenerative diseases.

TL;DR: The data indicate that cytochrome c release potentially contributes to the death of axotomized RGCs, suggesting that the cyto Chrome c release observed was injury-related.