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James J. Dowling

Researcher at University of Michigan

Publications -  131
Citations -  12656

James J. Dowling is an academic researcher from University of Michigan. The author has contributed to research in topics: Zebrafish & Medicine. The author has an hindex of 45, co-authored 108 publications receiving 10420 citations. Previous affiliations of James J. Dowling include Howard Hughes Medical Institute & University of Toronto.

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

Richard S. Finkel, +397 more
- 01 Nov 2017 - 
TL;DR: Those who received nusinersen were more likely to be alive and have improvements in motor function than those in the control group and infants with a shorter disease duration at screening wereMore likely than those with a longer disease duration to benefit from nusineren.
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Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

James J. Dowling, +2 more
- 15 Jul 1996 - 
TL;DR: The removal of the beta 4 gene in mice was targeted for understanding integrin function in cell-substratum adhesion, cell survival and differentiation, and for understanding the role of alpha 6 beta 4 in junctional epidermolysis bullosa, an often lethal human disorder with pathology similar to mice.
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Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

Clement Y. Chow, +13 more
- 05 Jul 2007 - 
TL;DR: A multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation in the ‘pale tremor’ mouse is described and a novel form of autosomal recessive Charcot–Marie–Tooth disorder is designated CMT4J.
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Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

Lifei Guo, +7 more
- 21 Apr 1995 - 
TL;DR: It is shown that in at least one other strain of dt/dt mice, BPAG1 gene is defective, and this compromises mechanical integrity and influences migration.