Karina R. Bortoluci

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A new context is introduced for interpreting (and reinterpreting) data from ex vivo studies with PerC MØ diversity, development, and function, as both subsets show clear phagocytic activity and both produce nitric oxide in response to LPS stimulation in vivo.

TL;DR: Some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs are discussed.

TL;DR: Foxp3+CD25+CD4+ regulatory T cells are vital for peripheral tolerance and control of tissue inflammation and expressed an effector/memory phenotype that distinguished them from naive Regulatory T cells (CCR4intCD62LlowCD44highCD54highCD69−), which efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.

TL;DR: It is shown that the Nlrp3 inflammasome is activated in response to Leishmania infection and is important for the restriction of parasite replication both in macrophages and in vivo as demonstrated through the infection of inflammaome-deficient mice with Leishmaniasis.