Gabriel Lopez-Berestein

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The role of fluid-expressedmiRNAs as reliable cancer biomarkers and treatment-response predictors as well as potential new patient selection criteria for clinical trials are discussed and the concept that miRNAs could function as hormones is explored.

TL;DR: Chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden and more invasive growth of ovarian carcinoma cells in an orthotopic mouse model, and β-adrenergic activation of the cAMP–PKA signaling pathway is identified as a major mechanism by which behavioral stress can enhance tumor angiogenesis in vivo and thereby promote malignant cell growth.

TL;DR: Levels of Dicer and Drosha mRNA in ovarian-cancer cells have associations with outcomes in patients with ovarian cancer, and functional assays indicated that gene silencing with shRNA, but not siRNA, may be impaired in cells with low Dicer expression.

TL;DR: Insight is provided into the regulatory mechanisms involved in the deregulation of miRNAs in cancer cells and the tumor microenvironment and therapeutic intervention strategies to overcome this deregulation are discussed.