W. Cam Patterson

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This work reports that VEGFR-2 is localized in endothelial caveolae, associated with caveolin-1, and that this complex is rapidly dissociated upon stimulation with VEGF, and observes that in an overexpression system in which VEG FR-1 is constitutively active, caveolin -1 overeexpression inhibits VEGfr-2 activity but allows VEGf-dependent activation, suggesting that caveolin can confer ligand dependency to a receptor system.

TL;DR: Experimental studies suggest that therapies that target misfolded proteins may have broad clinical application in neurodegenerative diseases and heart failure.

TL;DR: Regulation of chaperones such as HSP70 via activation of the JAK/STAT pathway suggests that in addition to its growth-promoting effects, this pathway may help VSMCs adapt to oxidative stress.

TL;DR: The crosstalk between the UPS and autophagy highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and regulating cardiovascular development and disease.