Hernan Roca

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A role for CCL2 and IL-6 in the survival of myeloid monocytes recruited to the tumor microenvironment and their differentiation toward tumor-promoting M2-type macrophages via inhibition of caspase-8 cleavage and enhanced autophagy is suggested.

TL;DR: BMP blocking agents were used to show that RUNX2‐dependent osteoblast differentiation and transactivation activity both require BMP signaling and, further, that RunX2 enhances the responsiveness of cells to BMPs.

TL;DR: A novel function of two TFs, OVOL1 and OVOL2, are demonstrated as critical inducers of MET in human cancers and their role as crucial regulators of epithelial-mesenchymal cell plasticity in cancer is suggested.

TL;DR: These studies allow us to begin understanding the complex mechanisms necessary to fine‐tune bone formation in response to extracellular stimuli including ECM interactions, mechanical loads, and hormonal stimulation.