Vijayasaradhi Setaluri

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this paper, the authors showed that MAGE-specific small interfering RNA suppresses S91 melanoma growth in vivo, in syngenic DBA2 mice and showed that suppression of class I MAGE proteins induces apoptosis in the Hs-294T, A375, and S91 MAGE positive melanoma cell lines and that members of all three families of MAGE class I proteins form complexes with KAP1, a scaffolding protein known as a corepressor of p53 expression and function.

TL;DR: In this paper, the authors investigated whether the loss of tyrosinase was due to proteolytic degradation, and they found that the degradation process was more prominent in malignant than in normal melanocytes and promoted the maturation and transit from the ER to the Golgi compartment.

TL;DR: The data demonstrate that the S100A4 gene controls the invasive potential of human CaP cells through regulation of MMP-9 and that this association may contribute to metastasis of CaP Cells.

TL;DR: It is proposed that rational microtubule-targeting cancer therapeutic approaches should ideally include proteomic profiling of tumor MAPs before administration of micro Tubule-stabilizing/destabilizing agents preferentially in combination with agents that modulate the expression of relevant MAPs.