Alessandro Fanzani

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The multifacetted therapeutic approach that is currently employed to prevent the development of muscle wasting and to counteract its progression is focused on, which includes adequate nutritional support, implementation of exercise training, and possible pharmacological compounds.

TL;DR: The results show that autophagy is induced in muscle in three different models of cancer cachexia and in glucocorticoid-treated mice, and the observation that in cancer hosts and tumor necrosis factor α-treated C2C12 myotubes, insulin can only partially blunt Autophagy induction suggests that autophileagy is triggered through mechanisms that cannot be circumvented by using classic upstream modulators.

TL;DR: Results demonstrate that ERK is involved in the pathogenesis of muscle wasting in cancer cachexia and could thus be proposed as a therapeutic target.