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Brian P. Rubin

Researcher at Cleveland Clinic

Publications -  295
Citations -  28671

Brian P. Rubin is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Sarcoma & GiST. The author has an hindex of 67, co-authored 269 publications receiving 24797 citations. Previous affiliations of Brian P. Rubin include Brigham and Women's Hospital & Case Western Reserve University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Diagnosis of gastrointestinal stromal tumors: A consensus approach.

Christopher D.M. Fletcher, +12 more
- 01 May 2002 - 
TL;DR: Key elements of the consensus are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time.
Journal Article

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

Brian P. Rubin, +12 more
- 15 Nov 2001 - 
TL;DR: It is suggested that activated KIT might represent a universal therapeutic target in GISTs, and mutations in all KIT domains were associated with high-level KIT activation/phosphorylation, and KITactivation was also demonstrated in the four Gists that lacked detectable KIT genomic and cDNA mutations.
Journal ArticleDOI

Gastrointestinal stromal tumour

Brian P. Rubin, +4 more
- 19 May 2007 - 
TL;DR: Targeting activated proteins with imatinib mesylate, a small-molecule kinase inhibitor, has proven useful in the treatment of recurrent or metastatic gastrointestinal stromal tumours and is now being tested as an adjuvant or neoadjuvant.
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Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Adam Abeshouse, +262 more
- 02 Nov 2017 - 
TL;DR: This large-scale analysis of 206 adult soft tissue sarcomas reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining Sarcoma therapy and relationships to other cancer types.