Andriy Nemchenko

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Recent progress in the fields of autophagy, apoptosis, and necrosis is reviewed and the involvement of these mechanisms in cardiac pathology is highlighted and potential translational implications are highlighted.

TL;DR: In this paper, the authors demonstrate that stress-induced protein aggregation is a proximal trigger of cardiomyocyte autophagy, which is a highly conserved process through which damaged proteins and organelles can be degraded.

TL;DR: The fundamental biology of autophagy and its role in a variety of forms of cardiovascular disease is reviewed, ways in which this evolutionarily conserved catabolic mechanism can be manipulated are discussed, studies presently underway in heart disease are reviewed, and the perspective on where this exciting field may lead in the future is provided.

TL;DR: The data support the cardioprotective actions of IGF-1, which, by rescuing the mitochondrial metabolism and the energetic state of cells, reduces cell death and controls the potentially harmful autophagic response to nutritional challenges.