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Mikel Garcia-Marcos

Researcher at Boston University

Publications -  78
Citations -  6809

Mikel Garcia-Marcos is an academic researcher from Boston University. The author has contributed to research in topics: Heterotrimeric G protein & G protein-coupled receptor. The author has an hindex of 27, co-authored 65 publications receiving 5545 citations. Previous affiliations of Mikel Garcia-Marcos include University of the Basque Country & University of California, Los Angeles.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

GIV is a nonreceptor GEF for Gαi with a unique motif that regulates Akt signaling

Mikel Garcia-Marcos, +2 more
- 03 Mar 2009 - 
TL;DR: The novel regulatory motif described here provides the structural and biochemical basis for the prometastatic features of GIV, making the functional disruption of this unique Gαi-GIV interface a promising target for therapy against cancer metastasis.
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A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

Pradipta Ghosh, +10 more
- 01 Jul 2010 - 
TL;DR: How this cellular decision is made is revealed by showing that a Gαi–GIV molecular complex interacts with EGF receptor and programs growth factor signaling, triggering migration when assembled and favoring mitosis when assembly is prevented.
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Activation of Galphai3 triggers cell migration via regulation of GIV.

Pradipta Ghosh, +3 more
- 28 Jul 2008 - 
TL;DR: Gαi3–GIV coupling is essential for cell migration during wound healing, macrophage chemotaxis, and tumor cell migration, indicating that the Gαi-GIV switch serves to link direction sensing from different families of chemotactic receptors to formation of the leading edge during cell migration.
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Hsp70-Bag3 interactions regulate cancer-related signaling networks

Teresa A. Colvin, +16 more
- 01 Sep 2014 - 
TL;DR: It is established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-κB, FoxM1, Hif1α, the translation regulator HuR, and the cell-cycle regulators p21 and survivin.