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Robert A. Baiocchi

Researcher at Ohio State University

Publications -  223
Citations -  12054

Robert A. Baiocchi is an academic researcher from Ohio State University. The author has contributed to research in topics: Protein arginine methyltransferase 5 & Mantle cell lymphoma. The author has an hindex of 47, co-authored 191 publications receiving 10068 citations. Previous affiliations of Robert A. Baiocchi include The Ohio State University Wexner Medical Center & James Cancer Hospital.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody

TL;DR: It is demonstrated that CT-011, a novel anti-PD-1 antibody, enhances humanNK-cell function against autologous, primary MM cells, seemingly through effects on NK-cell trafficking, immune complex formation with MM cells and cytotoxicity specifically toward PD-L1(+) MM tumor cells but not normal cells.
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A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells.

TL;DR: The data identify a new NK precursor and support a model of human NK development in which BM-derived CD34dimCD45RA(+)beta7bright HPCs reside in LN where endogenous cytokines drive their differentiation to CD56bright NK cells in vivo.
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Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

TL;DR: In vitro studies are the first to characterize a function for endogenous IL-15, and suggest an important role for IL- 15 during the innate immune response, which may be an important ligand for the NK cell IL-2 receptor in vivo.
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Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.

TL;DR: The studies indicate that aberrant expression of PRMT5 leads to altered epigenetic modification of chromatin, which in turn impacts transcriptional performance of anti‐cancer genes and growth of transformed lymphoid cells.