Wanda Christa Buzgariu

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is proposed that different types of injuries induce distinct cellular modes of Hydra head regeneration, which nonetheless converge on a central effector, Wnt3, which is reminiscent of proliferative blastemas in regenerating limbs and of compensatory proliferation induced by dying cells in Drosophila imaginal discs.

TL;DR: A complex immune response to injury is linked to wound healing and regeneration in Hydra, whereas the protease inhibitor α2macroglobulin gene exhibits a sustained up-regulation.

TL;DR: Cnidarian express orthologs for most components of the autophagy and TOR pathways suggesting evolutionarily-conserved roles during starvation and regeneration as Hydra survive weeks without feeding and regenerates any missing part after bisection.

TL;DR: Lack of epithelial stem cell renewal and deficient epithelial autophagy are the major causes of aging in Hydra oligactis, whereas lowering Autophagy efficiency in the non-aging Hydra vulgaris induces an aging phenotype.