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Hiroshi Koga

Researcher at Albert Einstein College of Medicine

Publications -  25
Citations -  8875

Hiroshi Koga is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Chaperone-mediated autophagy & Autophagy. The author has an hindex of 20, co-authored 24 publications receiving 7411 citations. Previous affiliations of Hiroshi Koga include Kyoto University & Yeshiva University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

Marta Martinez-Vicente, +12 more
- 01 May 2010 - 
TL;DR: It is proposed that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells.
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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

Joo-Yong Lee, +12 more
- 03 Mar 2010 - 
TL;DR: This study identifies HDAC6 and the actin cytoskeleton as critical components that define QC autophagy and uncovers a novel regulation of autophophagy at the level of Autophagosome–lysosome fusion.
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Interplay of LRRK2 with chaperone-mediated autophagy

Samantha J. Orenstein, +13 more
- 01 Apr 2013 - 
TL;DR: This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson’s disease–related protein degraded by this pathway.
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Protein Homeostasis and Aging: the importance of exquisite quality control

Hiroshi Koga, +2 more
- 01 Apr 2011 - 
TL;DR: Recent advances on the understanding of the contribution of chaperones and proteolytic systems to the maintenance of cellular homeostasis, the cellular response to stress and ultimately to longevity are reviewed.