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Lajos László

Researcher at Eötvös Loránd University

Publications -  78
Citations -  7900

Lajos László is an academic researcher from Eötvös Loránd University. The author has contributed to research in topics: Scrapie & Lysosome. The author has an hindex of 28, co-authored 77 publications receiving 6757 citations. Previous affiliations of Lajos László include University of the Sciences & University of California, San Francisco.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform.

A. Taraboulos, +5 more
- 01 Apr 1995 - 
TL;DR: It seems likely that both the initial degradation of Pr PC to the 17-kD polypeptide and the formation of PrPSc occur within a non-acidic compartment bound by cholesterol-rich membranes, possibly glycolipid-rich microdomains, where the metabolic fate of PrPC is determined.
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Mouse in Red ‐ Red Fluorescent Protein Expression in Mouse ES Cells, Embryos and Adult Animals

Kristina Vintersten, +7 more
- 01 Dec 2004 - 
TL;DR: The results show that the red fluorescent wavelength has a superior tissue penetrance compared with spectral variants of lower wavelength, and the Cre recombinase specificity on ES cell‐derived embryos/animals is verified.
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A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

Hermann M. Schätzl, +9 more
- 01 Nov 1997 - 
TL;DR: GT1 cells represent a novel system for studying the molecular mechanisms underlying prion infectivity and subsequent neurodegenerative changes and can be persistently infected with mouse RML prions and conditioned medium from infected cells could transfer prions to uninfected cells.
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Lysosomes as key organelles in the pathogenesis of prion encephalopathies.

Lajos László, +10 more
- 01 Apr 1992 - 
TL;DR: Immunogold electron microscopy is used to locate ubiquitin conjugates, hsp 70, and β‐glucuronidase (markers of the lysosomal compartment) and prion protein(PrP) in both control and scrapie‐infected mouse brain.